Yale scientists 'see' basis of antibiotic resistance

Using X-ray crystallography, researchers at Yale have "seen" the structural basis for antibiotic resistance to common pathogenic bacteria, facilitating design of a new class of antibiotic drugs

UT Southwestern researchers define regions of human genes highly prone to mutation

UT Southwestern Medical Center at Dallas researchers have taken the first step in defining the sites in human genes most prone to mutation

Aquaporins - the perfect water filters of the cell

Water regulation plays a crucial role in the human body

A cell-based screen for function of the four-helix bundle protein Rop: a new tool for combinatorial experiments in biophysics

The authors report a novel, robust, cell-based screen for function of the four-helix bundle protein, Rop.

BCM, Rice make major advance in structural biology

Noted expert: advance one of the field's most significant in two decades

Protein folding: Building a strong foundation

Study finds most stable parts of protein are the first to fold

Molecular motor implicated in tissue remodeling

A well-known enzyme present in the skin and other tissues turns out to be a molecule-sized motor that extracts its fuel from the road it runs on, according to researchers

Yale researchers find all of the gene targets for a protein

Using new DNA chip technology, Yale researchers have identified virtually all of the gene targets of some key proteins, known as transcription factors.

Yale scientists visualize molecular detail of RNA splicing complex

Scientists in the department of molecular biophysics and biochemistry at Yale revealed the crystal structure of the first described enzymatic RNA - what it looks like and how it reacts

Structure and Composition of the Fusion Pore

The fusion pore or porosome was shown to be a cup-shaped lipoprotein structure, the base of which has t-SNAREs and allows for docking and release of secretory products from membrane-bound vesicles.

Breakthrough: Scientists Create 3-D Map Of Cell Membrane Ion Pump At Near Atomic Resolution

Scientists have succeeded in mapping the structure of an ion pump in cells' plasma membrane - the "bag" that holds human and animal cells together and separates them from neighboring cells.

Voltage-Induced Nonconductive Pre-Pores and Metastable Single Pores in Unmodified Planar Lipid Bilayer

In the present work the authors studied the conductance changes associated with the formation of the metastable transient single pores in unmodified BLMs under high electric field.

Shear Force at the Cell-Matrix Interface: Enhanced Analysis for Microfabricated Post Array Detectors

In this article the authors studied the bending pattern of mPAD posts and found that shear force is the dominant force type applied by cells.

Molecular Dynamics Simulations of Hydrophilic Pores in Lipid Bilayers

In this study the authors present extended, atomistic molecular dynamics simulations that have been conducted to enable us to understand, in detail, the structure and dynamics of transient membrane pores...

'Micro-boxes' of water used to study single molecules

News: Researchers have demonstrated the use of water droplets as minuscule "boxes" for small numbers of biomolecules.

New microscope allows scientists to track a functioning protein with atomic-level precision

News: A Stanford University research team has designed the first microscope sensitive enough to track the real-time motion of a single protein down to the level of its individual atoms.

Theoretical comparison of the self diffusion and mutual diffusion of interacting membrane proteins

In this paper the authors analyze the interaction dependence of two important types of diffusional phenomena in bidmembranes: self diffusion and mutual diffusion.

World-leading microscope shows more detail than ever

News: A unique 3-dimensional microscope that works in a new way is giving unprecedented insight into microscopic internal structure and chemical composition.

Protein folding physics modeled at the atomic level

Researchers have created the first computer simulation of full-system protein folding thermodynamics at the atomic-level.

Study Pinpoints Rare Molecular 'Transitions' As Possible Cause Of Skin 'Photoaging'

Experimenting with lasers, hard-to-detect interactions between skin molecules and sunlight were discovered that eventually could cause the uncomplimentary changes characteristic of "photoaging."