Cell Pathway, Disease Linked To Histone Action

Researchers have discovered a key cell-signaling pathway that regulates cell progression and switches on front-to-back body patterning in tadpoles.

Toward Designing Medications To Enhance Innate Immunity: A Single VSOP Can Do 'Proton' Magic

International research group found that a single protein of VSOP, Voltage Sensor Only Protein/ Hv1, can carry protons even without making a multimeric complex.

Cancer: Why The Switch Stays On

Cellular processes, such as when to multiply, are often regulated by switches that control the frequency and timing of interactions between proteins.

Dividing Cells Find Their Middle By Following A Protein 'Contour Map'

Self-organization keeps schools of fish, flocks of birds and colonies of termites in sync.

Beyond Biology: Simple System Yields Custom-designed Proteins

The diversity of nature may be enormous, but for Michael Hecht it is just a starting point.

The Way A Protein Is Folded Affects The Molecular Dance Of Water

Scientists from Bochum, Illinois, and Nevada were able to prove with terahertz (THz) spectroscopy that proteins do modify water molecules in their environment to a long range extent:

Protein Folding: One Picture Per Millisecond Illuminates The Process

For the first time, chemists of Prof. Martina Havenith’s and Prof. Martin Gruebele’s group have “picturised” the spectacle of protein folding in water by THz spectroscopy.

Ricin

Ricin is protein toxin found in castor beans, and is applied as a purgative, an engine lubricant, and as a component of brake and hydraulic fluid.

Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver

Aquaglyceroporins form the subset of the aquaporin water channel family that is permeable to glycerol and certain small, uncharged solutes.

Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo

Available in vitro and in vivo methods for verifying protein substrates for posttranslational modifications via farnesylation or geranylgeranylation

Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain

These findings contribute to define the growing group of human polyserine proteases composed at present by three different proteins.

The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site

The present data show that the splicing factor SF3b1 is a substrate of the protein kinase DYRK1A and suggest that DYRK1A may be involved in the regulation of pre mRNA-splicing.

Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels

In an effort to investigate how loss of deneddylation affects SCF activity, the authors conditionally silenced the catalytic subunit of CSN in mammalian cells.

Discovering structural motifs using a structural alphabet: Application to magnesium-binding sites

The structural motif discovery method presented herein is general and can be applied to any set of proteins with known 3D structures.

New protein is essential for lung development

A recently discovered protein appears essential for lung development.

Misbehaving Molecules In ALS; 3-dimensional Pictures Of ALS Mutant Proteins Support Two Major Theories About How The Disease Is Caused

A new study reveals for the first time how gene mutations lead to the inherited form of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease.

UNC scientists solve mystery of how largest cellular motor protein powers movement

Scientists now understand how an important protein converts chemical energy to mechanical force

Mechanism For Neurodenegerative Diseases Linked To Transport Proteins

Hampering the transport of proteins within cells may underlie several adult-onset neurodegenerative diseases

Mutations In Transporter Protein Shed Light On Neurodegenerative Disorders

Researchers at Stanford University have made new discoveries that shed light on two inherited neurodegenerative disorders that are caused by inability of the body to transport sialic acid out of cellular compartments.

The loss of a protein favors lung tumor growth

The researcher Zafira Castaño has discovered that the loss of a protein in the early phases of lung cancer favors tumor growth.