Difference between revisions of "Transferrin receptor protein 2"

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'''Definition'''
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'''Transferrin receptor protein 2''' (TfR2) is a [[protein]] involved in the transport and delivery of [[iron]] to the [[liver]] and other [[tissues]]. In humans, this protein is coded by the ''TFR2'' gene mapped on [[chromosome]] 7q22. This gene gives origin to 2 alternatively spliced transcripts: (1) ''alpha-transcripts'' that encode a transmembrane protein and (2) ''beta-transcripts'', which is a shorter intracellular variant. As for the biological function, TfR2 mediates cellular uptakes of transferrin-bound iron in a non-iron dependent manner. Thus, this protein is implicated in iron metabolism, hepatocyte function, and [[erythrocyte]] differentiation. TfR2 helps sense and control iron storage levels in the body by calculating the height of another protein, ''hepcidin'', that determines how much iron is riveted from the diet and out from the storage sites in the body. It is associated with iron overload and tenders a tool for molecular diagnosis without HFE mutations. With regard to genetics, mutations involving the ''TFR2'' gene are responsible for the hereditary hemochromatosis. It is an iron metabolic disorder characterized by iron overload resulting from C282Y homozygosity in the HFE gene on chromosome 6p. Other ''TFR2'' mutations may result in incorrect amino acid sequence of TfR2 protein, and as a result, will be unable to regulate importation of iron into the cells. It also contributes to low-level hepcidin in the body, which in turn, leads to iron accumulation. In the liver, high levels of iron from lack of proper metabolism could lead to organ malfunction. Abbreviation: TfR2.
  
''noun''
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== See also ==
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* [[Transferrin]]
  
A [[protein]] involved in the [[transport]] and [[delivery]] of [[iron]] to the [[liver]] and other [[tissues]].
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==References ==
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# TFR2 transferrin receptor 2 [Homo sapiens (human)] - Gene - NCBI. (2019). Retrieved from Nih.gov website: https://www.ncbi.nlm.nih.gov/gene/7036
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# Genetics Home Reference. (2018). TFR2 gene. Retrieved from Genetics Home Reference website: https://ghr.nlm.nih.gov/gene/TFR2
  
'''Supplement'''
 
  
'''Transferrin receptor protein 2''' gene is mapped on [[chromosome]] 7q22 that gives origin to 2 alternatively spliced transcripts, alpha-transcripts which encodes a [[transmembrane]] protein and beta-transcripts a shorter intracellular variant. It mediates [[cellular]] uptakes of transferrin-bound iron in non-iron dependent manner, thus implicated in iron [[metabolism]], [[hepatocytes]] function and [[erythrocyte]] differentiation.
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© Biology Online. Content provided and moderated by '''[https://www.biology-online.org/about/ Biology Online Editors]'''
'''Transferrin receptor protein 2''' helps sense and control iron storage levels in the body by calculating the height of another protein [[hepcidin]] that determines how much iron is riveted from the diet and out from the storage sites in the body. It is associated in the iron overload and tenders a tool for [[molecular]] [[diagnosis]] without HFE mutations.
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'''Transferrin receptor protein 2''' gene[[ mutations]] is associated in hereditary [[hemochromatosis]] a disorder of iron metabolism characterized by iron overload resulted from C282Y homozygosity in the HFE gene on chromosome 6p. Other mutations results in proteins that have a wrong sequence of protein building blocks to function normally which likely  damage the capacity to regulate importation of iron into the cells. It is also drawn in to contributes the low level of hepcidin in the body which allows too much iron to be absorbed in the diet resulted in iron stored in the body tissues especially in the liver that leads to [[organ]] [[malfunction]].
 
 
 
'''Gene name:''' TFR2
 
 
 
'''Protein name:''' Transferrin receptor protein 2
 
 
 
'''Synonyms:'''
 
 
 
• [[HFE3]]
 
 
 
• [[TFR2_Human]]
 
 
 
'''See also:'''
 
 
 
• [[Transferrin]]
 
 
 
• [[Iron metabolism]]
 
 
 
• [[Protein]]
 

Latest revision as of 00:10, 20 October 2019

Transferrin receptor protein 2 (TfR2) is a protein involved in the transport and delivery of iron to the liver and other tissues. In humans, this protein is coded by the TFR2 gene mapped on chromosome 7q22. This gene gives origin to 2 alternatively spliced transcripts: (1) alpha-transcripts that encode a transmembrane protein and (2) beta-transcripts, which is a shorter intracellular variant. As for the biological function, TfR2 mediates cellular uptakes of transferrin-bound iron in a non-iron dependent manner. Thus, this protein is implicated in iron metabolism, hepatocyte function, and erythrocyte differentiation. TfR2 helps sense and control iron storage levels in the body by calculating the height of another protein, hepcidin, that determines how much iron is riveted from the diet and out from the storage sites in the body. It is associated with iron overload and tenders a tool for molecular diagnosis without HFE mutations. With regard to genetics, mutations involving the TFR2 gene are responsible for the hereditary hemochromatosis. It is an iron metabolic disorder characterized by iron overload resulting from C282Y homozygosity in the HFE gene on chromosome 6p. Other TFR2 mutations may result in incorrect amino acid sequence of TfR2 protein, and as a result, will be unable to regulate importation of iron into the cells. It also contributes to low-level hepcidin in the body, which in turn, leads to iron accumulation. In the liver, high levels of iron from lack of proper metabolism could lead to organ malfunction. Abbreviation: TfR2.

See also

References

  1. TFR2 transferrin receptor 2 [Homo sapiens (human)] - Gene - NCBI. (2019). Retrieved from Nih.gov website: https://www.ncbi.nlm.nih.gov/gene/7036
  2. Genetics Home Reference. (2018). TFR2 gene. Retrieved from Genetics Home Reference website: https://ghr.nlm.nih.gov/gene/TFR2



© Biology Online. Content provided and moderated by Biology Online Editors