Difference between revisions of "Specific granule"

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specific granule
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'''Specific granule''' refers to any of the secretory vesicles in the [[granulocyte]]s. It is one of the two major types of granules in granulocytes. The other is the azurophil granule. The specific granules are released more readily than the azurophil granules.  They are released by granulocytes (i.e. [[polymorphonuclear leukocyte]]s and mast cell]]s) through degranulation process in response to an immune stimulus. The presence of specific granules and the azurophil distinguishes the granulocytes from another type of leukocytes, the ''[[agranulocyte]]s'', which seem to lack both of these cytoplasmic granules under the light microscope.  Granulocytes store specific granules as a mixture of cytotoxic substances. [[Neutrophil]]s typically contain [[lactoferrin]], [[lysozyme]], NADPH oxidase, and alkaline phosphatase. [[Basophil]]s have [[heparin]] (as well as [[histamine]]). [[Eosinophil]]s have [[cathepsin]]. Synonym: secondary granule.
  
One of the two [[main]] [[classes]] of [[granules]] found in [[neutrophils]]: contain [[lactoferrin]], [[lysozyme]], [[vitamin B12]] [[binding]] [[protein]] and [[elastase]]. Are released more readily than the [[azurophil]] ([[primary]]) granules which have typical lysosmal [[contents]].
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== See also ==
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* [[Granulocyte]]
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* [[Lysozyme]]
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== References ==
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# Greer, J. P. & Wintrobe, M. M. (1 December 2008). Wintrobe's clinical hematology. Lippincott Williams & Wilkins. pp. 173–. https://books.google.com.ph/books?id=68enzUD7BVgC&pg=PA173&redir_esc=y#v=onepage&q&f=false
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Latest revision as of 07:11, 20 October 2019

Specific granule refers to any of the secretory vesicles in the granulocytes. It is one of the two major types of granules in granulocytes. The other is the azurophil granule. The specific granules are released more readily than the azurophil granules. They are released by granulocytes (i.e. polymorphonuclear leukocytes and mast cell]]s) through degranulation process in response to an immune stimulus. The presence of specific granules and the azurophil distinguishes the granulocytes from another type of leukocytes, the agranulocytes, which seem to lack both of these cytoplasmic granules under the light microscope. Granulocytes store specific granules as a mixture of cytotoxic substances. Neutrophils typically contain lactoferrin, lysozyme, NADPH oxidase, and alkaline phosphatase. Basophils have heparin (as well as histamine). Eosinophils have cathepsin. Synonym: secondary granule.

See also

References

  1. Greer, J. P. & Wintrobe, M. M. (1 December 2008). Wintrobe's clinical hematology. Lippincott Williams & Wilkins. pp. 173–. https://books.google.com.ph/books?id=68enzUD7BVgC&pg=PA173&redir_esc=y#v=onepage&q&f=false



© Biology Online. Content provided and moderated by Biology Online Editors