Platelet endothelial cell adhesion molecule
An adhesion molecule presents on platelets and endothelial cells involved in modulation of transendothelial migration, angiogenesis, integrin-mediated cell adhesion and regulation ofimmune cell signaling.
Platelet endothelial cell adhesion molecule gene is mapped onchromosome 17q23.3 containing 18 exons with a molecular weight of 82.5kDa that is found onmonocytes, neutrophils and T cells which is a member of immunoglobulin superfamily implicated in leukocyte migration and integrin activation which contributes to early cardiovascular development.
Platelet endothelial cell adhesion molecule is a cell surface molecule that prevents phagocyte ingestion of closely apposed viable cells by transmitting detachment signals and which changes function on apoptosis promoting tethering of dying cells to phagocytes. It is competent of complex ligand exchanges as well as the capacity to block normal endothelial cell-cell contacts and manipulates cell migration spot in angiogenesis and wound healing.
Platelet endothelial cell adhesion molecule confirmed to undergo phosphorylation ontyrosine residues following mechanical or biochemical stimulation. It is associated with beta-catenin in which overexpression resulted in recruitment of beta-catenin into cell-cell junctions and decrease in beta-catenin tyrosine phosphorylation levels.
Gene name: PECAM1
Protein name: Platelet endothelial cell adhesion molecule