Difference between revisions of "Cell adhesion"

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[[Cell adhesion]]
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'''Definition'''
  
See: [[adhesins]], cadherins, [[cell adhesion molecules]] (CAMs), [[contact]] [[sites]] a, DLVO [[theory]], [[integrins]], [[sorting out]], [[uvomorulin]] and various specialised [[junctions]] (adherens [[junctions]], [[desmosomes]], [[focal adhesions]], [[gap]] [[junction]] and [[zonula]] occludens).
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''noun''
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The binding of a [[cell]] to another [[cell]] or to an [[extracellular matrix]] [[component]], essential in [[organ]] formation during [[embryonic]] development and in conferring structural framework and [[tissue]] maintenance
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'''Supplement'''
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''Cell adhesion'' may be through:
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*''homophilic adhesion'' - where cell adhesion is facilitated by binding of similar [[adhesion]] [[molecule]]s
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*''heterophilic adhesion'' - where cell adhesion is facilitated by binding of unlike [[adhesion]] [[molecule]]s
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Without cell adhesion, the [[cell]]s will be fluid as it is in certain [[disease]]s such as [[metastatic]] [[cancer]] and [[osteoporosis]]. Cell adhesion is, therefore, essential in [[tissue]] formation, [[angiogenesis]], [[cell]] [[communication]], and [[cell]] [[regulation]].
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''Related term(s):''
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*[[cell adhesion molecule]]
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''Reference(s):''
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*Goodman SR. 2008. Cell Adhesion and the Extracellular Matrix. In: Medical cell biology.  3rd ed. London: Academic Press. p191-226.

Latest revision as of 10:16, 29 August 2011

Definition

noun

The binding of a cell to another cell or to an extracellular matrix component, essential in organ formation during embryonic development and in conferring structural framework and tissue maintenance


Supplement

Cell adhesion may be through:

  • homophilic adhesion - where cell adhesion is facilitated by binding of similar adhesion molecules
  • heterophilic adhesion - where cell adhesion is facilitated by binding of unlike adhesion molecules

Without cell adhesion, the cells will be fluid as it is in certain diseases such as metastatic cancer and osteoporosis. Cell adhesion is, therefore, essential in tissue formation, angiogenesis, cell communication, and cell regulation.


Related term(s):

Reference(s):

  • Goodman SR. 2008. Cell Adhesion and the Extracellular Matrix. In: Medical cell biology. 3rd ed. London: Academic Press. p191-226.