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(genetics) That which is associated with the Y chromosome


The term Y-linked is defined as that which is associated with the Y chromosome. In certain male animals such as mammals, including humans, the pair of sex chromosome is comprised of X chromosome and Y chromosome. The Y chromosome is considered as the male chromosome since it bears genes associated with male physical attributes, e.g. male gonads and appropriate hormone levels. The Y chromosome bears genes involved in sex determination. In particular, it bears the Sex-determining region Y (SRY) gene that codes for protein that initiates testicular development. Other sex-determining genes present in Y chromosome are those in the Azoospermia factor (AZF) region. AZF1 and AZF2 genes, in particular, are involved in sperm production. Nevertheless, there are also other genes present in the Y chromosome that are not for sex determination. Genes such as those coding for SOX-21 protein, acetylserotonin methyltransferase, zinc finger protein, amelogenin, interleukin-3 receptor, etc. occur in the Y chromosome. These genes, including those for sex determination, are referred to as Y-linked genes as being located in the Y chromosome. Inheritance of these genes on the Y chromosome is referred to as Y-linked inheritance.


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