From Biology-Online Dictionary | Biology-Online Dictionary


(Science: drug) A calcium channel blocking drug, used as a coronary vasodilator and antiarrhythmic.

pharmacologic action: calcium channel blockade, direct, potent negative chronotrope and inotrope, slows conduction in AV node, systemic and coronary vasodilation.

uses: supraventricular tachycardias.

dose: 2.5 - 5.0 mg iV over 1-2 minutes May repeat at 5.0 - 10 mg every 15-30 minutes until 30 mg total dose.

Onset: 3 - 5 min.

potential complications: hypotension due to vasodilation and depressed contractility. Treat with calcium; bradycardia, AV block can be exacerbated, contraindicated with congestive heart failure, synergistic interaction with beta blockers.

note: administration of verapamil to a patient with ventricular tachycardia can be lethal. Verapamil can accelerate heart rate and decrease blood pressure, especially in patients with Wolff-Parkinson-white and wide-complex tachycardia.