Vascular cell adhesion molecule 1
Vascular cell adhesion molecule 1 gene is mapped on chromosome 1p32-p31 that contains 9 exons which encodes cell surface sialoglycoprotein expressed by cytokine-activated endothelium and is upregulated in endothelium of postcapillary venules. The gene expression is regulated by transcription factors nuclear kappa B, SP-1 and interferon regulatory factor-1 induced by cytokine tumor necrosis factor and interleukin-1beta in which expression is blocked by scavenging superoxide dismutase.
Vascular cell adhesion molecule 1 activates endothelial cell nicotinamide adenine dinucleotide phosphate oxidase and mediates the adhesion of lymphocytes, monocytes, eosinophils and basophils to vascular endothelium. It plays a significant role in the development of atherosclerosis and rheumatoid arthritis. It is also expressed in lymph nodes andbone marrow for the regulation of leukocyte homing.
Vascular cell adhesion molecule 1 is induced on endothelial cells during inflammatory disease by several mediators including ROS (reactive oxygen species) which functions as both scaffold for leukocyte migration and trigger of endothelial signaling through NADPH oxidase generated ROS, thus VCAM-1 signaling is a target for intervention of pharmacological agents and antioxidants during inflammatory diseases.
Gene name: VCAM1
Protein name: Vascular cell adhesion protein 1
• Cluster of differentiation 106 (CD106)