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Tuberous sclerosis

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tuberous sclerosis

(Science: radiology) (bourneville disease) autosomal dominant phakomatosis classic triad: seizures, retardation, adenoma sebaceum, calcified subependymal hamartomas, uncalcified tubers in cerebral cortex, enhancing lesion most likely to be malignant transformation to giant cell astrocytoma associated with: skin lesions, angiomyolipoma, increased risk of renal cell carcinoma