Transcription factor HES 1

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Definition

noun

A protein involved in the maintenance of stem cells andprogenitor cells which influence the timing of differentiation and decide binary cell destiny.

Supplement

Transcription factor HES1 gene is mapped on chromosome 3q28-q29 containing four exons that belongs to the basic helix-loop-helix family of transcription factor which is important in myogenesis, neurogenesis, sex determination and hematopoiesis. It has a specific type of basic domain that contains a helix interrupting protein that binds to the N-box relatively to the E-box.

Transcription factor HES1 plays a significant role in nervous and digestive system and acts as regulator of myogenesis through inhibiting the function of MYOD1 as well as in FA core complex response to DNA cross-link breakage needed for the stability and nuclear localization of monoubiquitination of DNA damage.

Transcription factor HES1 is associated in negative regulation of transcription, liver development, ventricular septum development, outflow tract morphogenesis, protein complex assembly, Notch signaling pathway, embryonic heart tube morphogenesis and regulation of secondary heart field cardioblast proliferation.

Gene name: HES1

Protein name: Transcription factor HES-1

Synonyms:

HL

HRY

hHL

bHLHb39

FLJ20408

HES-1

Hairy homolog

Hairy-like protein

Hairy and enhancer of split 1

Class B basic helix-loop-helix protein 39

See also:

Protein

Helix-loop family