Toll-like receptor 7
Toll-like receptor 7 gene is mostly expressed in spleen, lungs and placenta where it only recognizes single strand RNA in endosomes, a common feature of viral genomes which is internalized by macrophages. It distinguishes pathogen-associated molecular patterns (PAMP) that activates on infectious agents to intercede the production of cytokines necessary for the advancement of effective immunity.
Toll-like receptor 7 has a profound effect on viral replication where it synergizes with RIG-I to induce a strong and as a crucial element in a pathway that contributes to the spread of CNS damage. It is also detect infections by extremely preserved mechanism of pathogens that normally seized in cellular compartment where it expressed intracellularly to identify nucleic acids since host and pathogen nucleic acids has awfully similar structures thereby face an extra challenge to induce anti-pathogen immune reactions while avoiding the stimulation of autoimmune disease.
Toll-like receptor 7 may offer a way to reduce the effect of various inflammatory pathways that are implicated in the development of psoriasis, a chronic inflammatory skin diseases that involves in the induction of T helper 1 cell as well as the abnormal expression of proinflammatory cytokines, thus irregular activation of these proteins contributes to the instigation for maintenance of psoriasis and other immune diseases.
Gene name: TLR7
Protein name: Toll-like receptor 7