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Tissue inhibitor of-metalloproteinase-3

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tissue inhibitor of-metalloproteinase-3

(Science: chemical) A member of the family of tissue inhibitor of metalloproteinases. It is a 21 kD, nonglycosylated protein. Timp-3 does not show a high degree of structural similarity unlike timp-1 and timp-2 which are structurally similar. However, it does possess a high degree of structural similarity with that of chicken timp-3 (chimp-3). Human timp-3 is of particular concern because of its potential role in cancer, arthritis, and eye diseases.

Pharmacological action: antineoplastic agent, protease inhibitors.