Tissue inhibitor-of metalloproteinase-2

From Biology-Online Dictionary | Biology-Online Dictionary

tissue inhibitor-of metalloproteinase-2

(Science: chemical) A member of the family of tissue inhibitor of metalloproteinases. It is a 21 kD nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase a by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of timp-2 has been shown to inhibit invasive and metastatic activity of tumour cells and decrease tumour growth in vivo.

Pharmacological action: antineoplastic agent, protease inhibitors.