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Thromboxane A2

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Definition

noun, plural: thromboxanes A2

A thromboxane, with a chemical formula of C20H32O5, has a bicyclic oxaneoxetane structure, produced by the platelets, and acts as a potent inducer of platelet aggregation and vasoconstriction; thromboxa-5,13-dien-1-oic acid, 9,11-epoxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-



Supplement

Eicosanoid is the generic term to refer to the compounds derived from arachidonic acid or other polyunsaturated fatty acids of 20-carbon length. Thromboxanes are one of the groups of eicosanoids. Thromboxanes are produced biosynthetically by activated platelets. Within the cell, prostaglandin cyclic endoperoxides, e.g. prostaglandin H2, are converted into thromboxanes through the aid of the enzymes, thromboxane synthases. The thromboxanes are characterized by having a six-membered ether-containing ring and their role in thrombosis. Two of the major thromboxanes are thromboxane A2 (TxA2) and thromboxane B2 (TxB2).

TxA2 has a bicyclic oxaneoxetane structure. It has a chemical formula of C20H34O6. The compound is a potent inducer of platelet aggregation and causes vasoconstriction. The activation of platelets leads to the further production of TxA2. TxA2 is believed to be responsible for Prinzmetal's angina. It is the principal component of rabbit aorta contracting substance (rcs).

The thromboxane A2 receptors are the receptors mediating the action of TxA2. The inactive metabolite or product of thromboxane A2 is thromboxane B2.


Chemical formula:

  • C20H34O5

See also: