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Teniposide

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teniposide

(Science: chemical) A cytotoxic semisynthetic derivative of podophyllotoxin that may be effective in cancer chemotherapy. It prevents cells from entering the prophase of mitosis and inhibits dNA synthesis.

Pharmacological action: antineoplastic agent, phytogenic, nucleic acid synthesis inhibitors.

Chemical name: Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-