Tenascin-R is a member of extracellular glycoprotein matrix that is primary found in nervous system in which it affects on cell migration, differentiation and adhesion. Its expression outlines certain role in neurological problems such as neurodegenerative disorder, malformation and tumors. It is detected largely in nervous system that localized roughly around motor neurons and motor axons in spinal cord, olfactory bulb, hippocampus and cerebellum that plays a significant role in instigating the detachment of the neuroblasts from tangential chain.
Tenascin-R is aprotein involved in interactions with different cell and matrix components that able to influence cellular behavior through evoking a stable adhesion and differentiation of the neural growth.
Tenascin-R comprises three genes in mammals that are distinctly expressed in tissues at different times for the period of embryonic development which hang about in adult tissues. When it is linked with chondroitin sulfate glycosaminoglycans, mediates the inhibition of cell adhesion and neurite outgrowth, thus the sulfated carbohydrate structure of Tenascin-R may modulate the adhesive properties over the course of development and synapse maintenance.
Gene name: TNR
Protein name: Tenascin-R