Superoxide dismutase 3
Superoxide dismutase 3 genes are mapped on chromosome 4p15.3-p15.1 that contains 2 exons which found in plasma, lymph, synovial fluid andtissues. It is a tetrameric glycoprotein with a molecular mass of about 30kD that consists of synthesized enzyme with putative 18 amino acids signal peptide prior the 222 amino acids in the mature enzyme indicating as a secretory protein. It is predominantly present in adult heart, placenta, pancreas, lung, thyroid and uterus and a minimal expression in skeletal muscle, kidney and liver.
Superoxide dismutase 3 is associated in reduced lung functions and susceptibility to chronic obstructive pulmonary disease as well as implicated as contributing factor to altered ventilation efficiency. Its level in plasma is age-dependent in which peaking in early childhood as lung develops and decreased during adult that possibly provides unfavorable lung function development and successive vulnerability to disease.
Superoxide dismutase 3 in vascular system unites on the surface of endothelial cells through the heparan sulfate proteoglycan that eradicates the oxygen radicals from the NADP dependent oxidative system of neutrophils. It has a promising role in determining lung function in children wherein SOD3 promoter region derived oligonucleotides holding C variants is more effectual in opposing with nuclear protein binding capacity associated risk of lung function decline in COPD.
Gene name: SOD3
Protein name: Extracellular superoxide dismutase