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Superoxide dismutase 3

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Definition

noun

An enzyme involved as antioxidant that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen that primarily protects the extracellular matrix of the lung.

Supplement

Superoxide dismutase 3 genes are mapped on chromosome 4p15.3-p15.1 that contains 2 exons which found in plasma, lymph, synovial fluid andtissues. It is a tetrameric glycoprotein with a molecular mass of about 30kD that consists of synthesized enzyme with putative 18 amino acids signal peptide prior the 222 amino acids in the mature enzyme indicating as a secretory protein. It is predominantly present in adult heart, placenta, pancreas, lung, thyroid and uterus and a minimal expression in skeletal muscle, kidney and liver.

Superoxide dismutase 3 is associated in reduced lung functions and susceptibility to chronic obstructive pulmonary disease as well as implicated as contributing factor to altered ventilation efficiency. Its level in plasma is age-dependent in which peaking in early childhood as lung develops and decreased during adult that possibly provides unfavorable lung function development and successive vulnerability to disease.

Superoxide dismutase 3 in vascular system unites on the surface of endothelial cells through the heparan sulfate proteoglycan that eradicates the oxygen radicals from the NADP dependent oxidative system of neutrophils. It has a promising role in determining lung function in children wherein SOD3 promoter region derived oligonucleotides holding C variants is more effectual in opposing with nuclear protein binding capacity associated risk of lung function decline in COPD.

Gene name: SOD3

Protein name: Extracellular superoxide dismutase

Synonym:

EC-SOD

See also:

Superoxide dismutase

Enzyme

Heparan