Superoxide Dismutase 2
Superoxide Dismutase 2 genes is mapped onchromosome 6q25.3 that contains 5 exons span at about 20kb which has a genomic sequence of 5-prime flanking region contains no TATA or CAAT but abundant of GC. It is a member of iron/manganese superoxide dismutase family.
Superoxide Dismutase 2 is a mitochondrial matrix enzyme that scavenges oxygen radicals produced by the extensive oxidation-reduction and electron transport reactions happen in the mitochondria. It is tetrameric that contains manganese.
Superoxide Dismutase 2 gene mutation is associated with idiopathic cardiomyopathy premature aging, sporadic motor neuron diseases and cancer. A study reveals that SOD2 needed for normal biologic function of tissues by upholding the veracity of mitochondrial enzymes vulnerable to direct inactivation by superoxide. It is also associated in suppression of optic nerve degeneration and rescue of retinal ganglion cells, thus contributes to the retinal cell death and optic nerve damage.
Gene name: SOD2
Protein name: Superoxide dismutase, mitochondrial