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(Science: immunology) antigens, mostly from bacterial toxins, that interact with a set of t lymphocytes bearing a set of products of the V_T receptor genes, as a consequence superantigens activate large numbers of t-cells.

staphylococcal enterotoxins are the best known superantigens and stimulate cD4 t-cells in humans. The mls gene product in mice can act as a superantigen.