Splase

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splase

(Science: enzyme) Constructed by genetically fusing the dNA-cleavage domain of foki restriction endonuclease with the zinc-finger DNA-binding domain of transcription factor sp1; recognises a 10-bp sequence of the long terminal repeat of hiv-1 DNA at sp1 sites and cleaves phosphodiester bonds upstream of thebinding sequence

Registry number: EC 3.1.21.-