Specificity protein 1
Specificity protein 1 gene is mapped on chromosome 12q13.1 that contains 785 amino acids with a molecular weight of 81kDa encodes a transcription factors which upregulates or downregulates in response to physiological and pathological stimuli. It has three transcript variants encoding in different isoforms found in this gene.
Specificity protein 1 binds with high affinity to GC rich sequence that regulates expression of an arrangement of genes drawn in various cellular processes such as growth, differentiation, immune response and apoptosis which in turn modulates cell responses to DNA damage implicated in chromatin remodeling. It binds to the PDGFR-alpha G-box promoter that modulates the cell response to DNA damage as well as functions in the recruitment of SMARCA4 on the c-FOS promoter and necessary in the regulation of FE65 gene expression.
Specificity protein 1 is extremely regulated by post translational modification like phosphorylation, proteolytic cleavage, sumoylation, acetylation and glycosylation furthermore SP1 cis-sites in the promoter region could offer additional echelon of transcriptional regulation resulted as a fundamental activator of basal SYN1 gene expressions whose activity is modulated by neural master regulator.
Gene name: SP1
Protein name: Transcription factor Sp1