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Somogyi phenomenon

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A rebound phenomenon as proposed by Michael Somogyi, an American biochemist, to describe the occurrence of reactive hyperglycemia following an episode of hypoglycemia in diabetis mellitus


The possible cause of this phenomenon is the excessive administration of insulin. It causes a sudden drop of blood glucose beyond the normal level (hypoglycemia). This, in turn, incites counter-regulatory response, i.e. the release of epinephrine, ACTH, glucagon, and growth hormone, increasing blood sugar above the normal level (hyperglycemia).



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