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Shwartzman reaction

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Shwartzman reaction

(Science: investigation) reaction that occurs when two injections of endotoxin are given to the same animal, particularly rabbits, 24h apart. In the local shwartzman reaction the first injection is given intradermally, the second intravenously and a haemorrhagic reaction develops at the dermal site. If both injections are intravenous the result is a generalised Shwartzman reaction, often accompanied by disseminated intravascular coagulation. The reaction depends upon the response of platelets and neutrophils to endotoxin.