Serum-inducible kinase gene is mapped on chromosome 5q12.1-q13.2 containing 14 exons with alternatively spliced variants encoding in different isoforms. It functions by binding and phosphorylating proteins on a specific motif recognized by box domain and plays a vital role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling.
Serum-inducible kinase is predominantly expressed intestis, fetal tissues, lung, kidney, heart and spleen where it is induced by serum that is significant in cells that undergo rapid cell division. It also control the cell cycle checkpoint and cell cycle progression which is important in having high mitotic index.
Serum-inducible kinase is implicated in synucleinopathies wherein overexpression of PLK2 reduces alpha-syn induced toxicity and motor deficits thus, PLK2 support the neuroprotective role in modulating its activity through viable therapeutic strategy for the treatment of Parkinson’s disease and related synucleinopathies.
Gene name: PLK2
Protein name: Serine/threonine-protein kinase PLK2