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Rosette formation

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rosette formation

The in vitro formation of clusters consisting of a cell (usually a lymphocyte) surrounded by antigenic cells or antigen-bearing particles (usually erythrocytes, which may or may not be coated with antibody or antibody and complement). The rosette-forming cell may be an antibody-forming cell, a memory cell, a t-cell, a cell bearing surface cytophilic antibodies, or a monocyte possessing fc receptors. Rosette formation can be used to identify specific populations of these cells.