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Rioprostil

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rioprostil

(Science: chemical) (11 alpha,13e)-1,11,16-trihydroxy-16-methylprost-13-en-9-one. A synthetic methylprostaglandin e1 analog that reduces gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of gastric ulcers and gives significant protection against nsaid-induced gastric mucosal damage. The drug also prevents cyclosporin a-induced damage to endocrine and exocrine pancreatic secretions. It shows a low order of acute toxicity and there is no evidence of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies.

Pharmacological action: anti-ulcer agents.

Chemical name: Prost-13-en-9-one, 1,11,16-trihydroxy-16-methyl-, (11alpha,13E)-