Retinoblastoma-like protein 2
Retinoblastoma-like protein 2 gene is mapped on chromosome 16q12.2 containing 22 exons span at about 57.1bp and 1139 amino acids that comprised of 286 sequences from 262 cDNA clones produced nine different alternative splicing isoforms in which differs in truncation of N-terminus and C-terminus with the presence or absence of cassette exon. It is ubiquitously expressed innormal tissues.
Retinoblastoma-like protein 2 is a protein inhibitor of E2F-mediated trans-activation that associates preferentially with E2F5. It shows important role in cell cycle regulation, proliferation and differentiation at some point in placental development. It also binds to cyclin A and E as well as linked in the transforming capacity of the adenovirus E1A protein.
Retinoblastoma-like protein 2 plays in modulation of the senescence, a cellular aging reliant on the regular physiological functions of non-immortalized cells. It is also implicated as oncosuppressor gene inbreast cancer, choriodal melanoma, endometrial cancer, Burkitt’s lymphoma, lung cancer, mesothelioma, ovarian cancer and vulvar carcinoma.
Gene name: RBL2
Protein name: Retinoblastoma-like protein 2