Retinoblastoma-like protein 1
Retinoblastoma-like protein 1 gene is mapped on chromosome 20q11.2 that contains 22 exons span at about 100kb in two transcript variants isoforms. Its cDNA encodes 936 protein residues with homology of extending region over 564 residues wherein this region is necessary for its growth controlling function as such the extreme N-terminal and C-terminal reveals the most preserved between two sequences.
Retinoblastoma-like protein 1 has a possible function to the retinoblastoma1 gene, a tumor suppressor protein that involved in cell cycle regulation as it is regulated in the S and M phase transition. It involved in heterochromatin formation during cell division by maintaining the structures through stabilizinghistone methylation thereby manifest histone methytransferases that leads to epigenetic transcription repression.
Retinoblastoma-like protein 1 can inhibits the transcription of cell cycle containing E2F binding sites promoters which is thought to be a tumor suppressor. Its overexpression may modulate the Notch1 pathway and negatively regulates the neural stem cells in developingbrain as well as in an adult brain.
Gene name: RBL1
Protein name: Retinoblastoma-like protein 1