noun, plural: resolvins
Eicosanoid is the generic term to refer to the compounds derived from arachidonic acid or other polyunsaturated fatty acids of 20-carbon length. Some of the prominent eicosanoids include (1) eoxins, (2) leukotrienes, (3) lipoxins, (4) prostacyclin, (5) prostaglandins, (6) resolvins, and (7) thromboxanes.
Resolvin is an eicosanoid that is produced naturally from omega-3 fatty acids: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). It may also be derived from docosapentaenoic acid (DPA) and clupanodonic acid. It has hormone-like activity, acting on local tissues. It may be involved in tissue repair process, particularly in the restoration of the normal function of a cell after inflammation.
Resolvins may also be regarded as one of the specialized proresolving mediators (SPMs) under the larger group of polyunsaturated fatty acid (PUFA) metabolites. Resolvins, in turn, are divided into sub-groups based on the PUFA that they are derived from. For instance, resolvins Ds are resolvins formed from DHA (i.e. a 22-carbon PUFA). Resolvin Es are compounds from EPA (i.e. a 20-carbon PUFA). Oxygenases are the enzymes that act on the conversion of PUFA into resolvins.