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Replication Factor C

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An important DNA polymerase protein that is necessary for various features of DNA metabolisms, replication and repair.


Replication Factor C is a heteropentameric that consists of five subunits such as RFC1, RFC2, RFC3, RFC4 and RFC5 that used as a clamp loader engage in catalyzing the PCNA to DNA where it binds at the 3’ end of the DNA and utilizes ATP to open the ring of PCNA to encircle the DNA, thus ATP hydrolysis cause release of RFC into DNA. All this subunits contribute to a linked sequence that includes nucleotide binding chain and mapped on different chromosome location such as RFC1 mapped to 4p14-p13, RFC2 mapped to 7q11.23, RFC3 mapped to 13q12.3-q13, RFC4 mapped to 3q27, RFC5 mapped to 12q24.2-q24.3.

Replication Factor C is a multimeric primer protein that in human has been purified from the HeLa cells as a host factor essential for the replication of Simian virus 40 DNA.

Replication Factor C subunit1 binds to the primer template junction which could act in DNA transcription and replication that could bind single or double DNA strand.

Replication factor C subunit 2 direct to abridged efficiency of DNA replication which account for growth deficiency as well as developmental disorder.

Gene name: RFC1

Protein name: Replication factor C


Activator 1 140 kDa subunit

A ctivator-1


See also:

DNA polymerase