Stuck on a problem? Get great tutoring at an affordable price with Chegg. Click here to join and get your 1st 30 minutes Free!

Receptors macrophage colony-stimulating factor

From Biology-Online Dictionary
Jump to: navigation, search

receptors, macrophage colony-stimulating factor

glycoproteins of mw 165 kD which are encoded by the c-fms proto-oncogene. The binding of csf-1 to its receptors activates an intrinsic tyrosine kinase activity resulting in autophosphorylation of the receptors on tyrosine, rapid receptor down-regulation, and phosphorylation of as yet unidentified physiologic substrates that initiate a mitogenic response.