Purinoceptor P2X4 gene is mapped on chromosome 12q24.32 gated by adenosine-triphosphate and other nucleotides where it leads to the opening of much larger pores permitting large molecules to pass through the cell membrane, thus this increased permeability quickly escort cell death and lysis. It is expressed in the endothelial cell that functions in response to the changes in the blood flow consequently, it is crucial to flow-sensitive mechanism that regulates blood pressure and vascular remodeling.
Purinoceptor P2X4 is needed for tactile allodynia in response to nerve injury since its action in the spinal microglia and peripheral macrophages instigate pain hypersensitivity caused by inflammation and injury to a peripheral nerve. It is widely expressed inbrain, lung, thymus, spinal cord, bladder, testis, adrenal and vas deferens.
Gene name: P2RX4
Protein name: P2X purinoceptor 4