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From Biology-Online Dictionary
(1) An autonomously folding functional unit of a protein.
(2) A part of protein that can fold, function and exist independently of the rest of the protein chain or structure.
Protein domains vary in length. Some can consist of about 25 amino acids while others up to 500 amino acids in length. Zinc fingers are an example of small protein domains that can coordinate one or more zinc ions to help stabilize their folds.