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Prostaglandin B

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Definition

noun, plural: prostaglandins B

Any of the physiologically active prostaglandins found in many tissues and organs, and may be produced from prostaglandin A or from prostaglandin E


Supplement

Prostaglandin is an eicosanoid that is derived from unsaturated 20-carbon fatty acids, such as arachidonic acid, through the cyclooxygenase pathway. There are several prostaglandins and they are designated by appending a letter, i.e. from A to I, to indicate the type of substituents found on the hydrocarbon skeleton. Prostaglandin As are derived from the dehydration of the prostaglandin E series. The rearrangement of the double bond within the cyclopentane ring of Prostaglandin As gives rise to the prostaglandin Bs. Thus, PGAs may serve as metabolites to the prostaglandin B, as well as prostaglandin C. In particular, prostaglandin A is initially converted by specific enzymes into prostaglandin C. The prostaglandin C, in turn, is converted into prostaglandin B through base-catalyzed process. Prostaglandin B may also be produced from prostaglandin E, e.g. by treating prostaglandin E with a strong base.

Prostaglandin Bs are physiologically active prostaglandins. They are potent pressor substances and have many other physiological activities. Examples of prostaglandin B series are prostaglandin B1, prostaglandin B2, prostaglandin B3...

The conversion of prostaglandin A intoprostaglandin B also takes place in living organisms. Prostaglandin A is converted by the PGA isomerase enzyme system into prostaglandin C from which


Abbreviation/Acronym:

  • PGB

See also: