Prostaglandin A (or PGA) is a vasodilating prostaglandin series. Prostaglandins are eicosanoids derived from unsaturated 20-carbon fatty acids (e.g. arachidonic acid) through the cyclooxygenase pathway. PGA, in particular, is derived from the dehydration of the prostaglandin E series. In turn, PGA converts into prostaglandin B by a rearrangement in the double bond within its cyclopentane ring.
PGA is a potent vasodilator, capable of dilating peripheral blood vessels and thereby lower arterial pressure.1 It is also presumed as a natriuretic hormone. It may be acting as a circulating hormone that controls the reabsorption of sodium by the kidney.2
Types of PGA are PGA1 and PGA2. PGA1 (molecular formula: C20H32O4) is characterized by a cyclopentenone structure. It is first discovered in marine organisms, like corals. PGA2 (molecular formula: C20H30O4) is also produced by corals as self-defense mechanism. Both PGA1 and PGA2 occur naturally. In contrast, PGA analogs are not present in nature but are made artificially. They are referred to as synthetic PGAs. Abbreviation: PGA
- Anderson, R. J., Berl, T., McDonald, K. M., & Schrier, R. W. (1976). Prostaglandins: Effects on blood pressure, renal blood flow, sodium and water excretion. Kidney International, 10(3), 205–215. https://doi.org/10.1038/ki.1976.99
- Jones, R. L. (1972). Functions of prostaglandins. Pathobiol Annu. 2:359-80.
- Prostaglandin A2 (CAS 13345-50-1). (2019). Retrieved from Caymanchem.com website: https://www.caymanchem.com/product/10210/prostaglandin-a2
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