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noun, plural: prolymphocytes

An immature lymphocyte intermediate between the lymphoblast and the mature lymphocyte in the lymphocytic series


Hematopoiesis is the process of forming new blood cellular elements in vertebrates. In this regard, lymphopoiesis is a hematopoiesis leading to the formation of lymphocytes. It begins with a multipotent stem cell, a hemocytoblast, which gives rise to a common myeloid progenitor cell. The progenitor cell, in turn, gives rise to colony forming unit (particularly, CFU-L) fated to become lymphocytes. In the lymphocytic series, the first cell stage is called lymphoblast. This cell gives rise to the prolymphocytes. A prolymphocyte is a cell that develops to become a mature lymphocyte. However, there are instances wherein certain mature lymphocytes can revert to lymphoblast through antigenic stimulation. When this happens, the lymphocyte re-enters the S phase of the cell cycle and subsequently, mitogenesis.

A prolymphocyte has a large, round bluish nucleolus, indistinct parachromatin, centrally located nucleus, and 5:1 to 3:1 nucleus:cytoplasm ratio. When stained with conventional dyes, the cytoplasm renders medium to deep homogenous blue color.1

See also:

Related form(s):

  • prolymphoblastic (adjective)

1 prolymphocyte. (n.d.) McGraw-Hill Concise Dictionary of Modern Medicine. (2002). Retrieved from