noun, plural: prolymphocytes
Hematopoiesis is the process of forming new blood cellular elements in vertebrates. In this regard, lymphopoiesis is a hematopoiesis leading to the formation of lymphocytes. It begins with a multipotent stem cell, a hemocytoblast, which gives rise to a common myeloid progenitor cell. The progenitor cell, in turn, gives rise to colony forming unit (particularly, CFU-L) fated to become lymphocytes. In the lymphocytic series, the first cell stage is called lymphoblast. This cell gives rise to the prolymphocytes. A prolymphocyte is a cell that develops to become a mature lymphocyte. However, there are instances wherein certain mature lymphocytes can revert to lymphoblast through antigenic stimulation. When this happens, the lymphocyte re-enters the S phase of the cell cycle and subsequently, mitogenesis.
A prolymphocyte has a large, round bluish nucleolus, indistinct parachromatin, centrally located nucleus, and 5:1 to 3:1 nucleus:cytoplasm ratio. When stained with conventional dyes, the cytoplasm renders medium to deep homogenous blue color.1
- prolymphoblastic (adjective)
1 prolymphocyte. (n.d.) McGraw-Hill Concise Dictionary of Modern Medicine. (2002). Retrieved from https://medical-dictionary.thefreedictionary.com/prolymphocyte