It differs chemically from procaine by containing the amide group (CONH) instead of the ester group (COO). It depresses the irritability of the cardiac muscle, having a quinidine-like action upon the heart, and is used in ventricular arrhythmias.
Pharmacological action: anti-arrhythmia agents, platelet aggregation inhibitors. Suppresses ventricular ectopy by slowing phase 4 diastolic depolarisation, reducing automaticity. Slows conduction and may prevent reentrant rhythms.
(12 M 350 ar 2000)