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Placental growth factor

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A glycosylated dimeric secretedprotein that able to stimulate endothelial cell growth and a key molecule in pathological angiogenic events during embryogenesis.


Placental growth factor codes for an angiogenic factors expressed in placentaltissue and is located on chromosome 14 that has been conserved in evolution. It belongs to the family of vascular endothelial growth factors that binds to VEGF receptor that significantly plays an important role in angiogenic events with exerting its biological activities.

Placental growth factor main source during pregnancy is the placental trophoblast which is also expressed in other tissues. It also regulates inter and intra molecular cross talk between vascular endothelial growth factor and fms-like tyrosine kinase that motivates phosphorylation of specific tyrosine residues and the expression of discrete downstream target genes.

Placental growth factor is distorted in women with preeclampsia wherein during pregnancy the normal maternal serum levels of soluble fms-like tyrosine kinase is significantly increased while those with preeclampsia is decreased which suggest that placental concentrations emulate the maternal serum changes wherein women who in time got the condition the blood vessels in the placenta narrow instead of broaden resulting high blood pressure. It is also involved in atherosclerotic lesions linked with plaque swelling and neovascular growth.

Acronym: PGF/PlGF

Gene name: PGF

Protein name: Placenta growth factor (PlGF)





See also:

Growth factors