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noun, plural: pestiviruses

(virology) A genus of viruses in the taxonomic family Flaviviridae, characterized by their enveloped icosahedral structure, 50nm diameter, non-segmented linear RNA genome of 12kb in length, and infect mammals such as cattle, sheep, swine, and goats


Flaviviridae is a taxonomic family comprised of viruses containing monopartite, linear, single-stranded RNA enveloped with icosahedral, spherical structure (about 40-60 nm in diameter). This family includes four genera: Flavivirus, Hepacivirus, Pegivirus, and Pestivirus.

Pestiviruses are viruses from the genus Pestivirus. The genus includes viruses that use mammals, e.g. cattle, sheep, swine, and goats, as natural host. These viruses are enveloped and with icosahedral-like structure. The diameter is around 50 nm. Their genome is a monopartite, linear, single-stranded RNA with 12kb in length. Their mode of entry into the host cell is by clathrin-mediated endocytosis. Inside the host cell, they replicate in the cytoplasm by following the positive stranded RNA virus replication model. They leave the host cell by budding.

One of the species of this genus is the Bovine viral diarrhea virus 1, the virus causing bovine viral diarrhea in cattle. Other diseases associated with this genus are hemorrhagic syndromes and fatal mucosal disease.

Scientific classification:

  • Family: Flaviviridae
  • Genus: Pestivirus

See also: