Peroxiredoxin 5 gene is mapped on chromosome on 11q13.1 that displays mitochondrial presequence and 3 cysteines involved in antioxidant activity with C-terminal peroxisomal sequence. It localizes in fibroblasts of normal tendon and endothelial cells of degenerative tendon. It also interacts with peroxisome receptor 1 which used translation initiation sites to produced mitochondrial forms. Its crystal structure has been resolved to 1.5 angstrom resolution and contains three transcript variants isoforms.
Peroxiredoxin 5 reduces hydrogen peroxide and alkyl hydroperoxides that acts as antioxidant on different tissues under normal conditions and inflammatory processes through thioredoxin system. It has an antioxidant capacity equivalent to CAT that involved in intracellular redox signaling.
Peroxiredoxin 5 a peroxidase that lessen hydrogen peroxides 10 times faster than free cysteine that shows hydrogen bonds in the active sites which makes two possible catalysis such as enhancement of thiolate nucleophilicity upon substrate ingress and stabilization of transition state.
Gene name: PRDX5
Protein name: Peroxiredoxin-5, mitochondrial