Peroxiredoxin 1 gene is mapped on chromosome 1p34.1 and a member of peroxiredoxin family that contains a consensus site (Thr(90)-Pro-Lys-Lys) for phosphorylation by cyclin dependentkinases. This protein reduces the peroxidase activity by 80% through the thioredoxin system. Its phosphorylation is marked during mitosis yet undetectable at interphase, thus prevents the interaction of CDKs until breakdown of nuclear envelope during mitosis.
Peroxiredoxin 1 is implicated in redox regulation of the cell and plays an important role in eliminating peroxides produced during metabolism that participates in signaling of growth factors and tumornecrosis factor-alpha through regulating the intracellular concentrations of H2O2. It also stimulates TLR4 dependent cytokine secretion from macrophages and dendritic cells.
Peroxiredoxin 1 is overexpressed in several cancer cells including esophageal, pancreatic, lung,thyroid and oral cancer. Its concentration can be secreted by non-small cell lung cancer cells via unusual pathway. It is needed to activate Gde2 by reducing an intramolecular cysteine connection between N and C terminal domains for the induction of motor neuron differentiation.
Gene name: PRDX1
Protein name: Peroxiredoxin-1
• Natural killer cell-enhancing factor A (NKEF-A)