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Peroxiredoxin 1

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A protein that is responsible in antiviral activities and thermal stress defense mechanisms through regulation of hydrogen peroxide signaling and protein chaperone.


Peroxiredoxin 1 gene is mapped on chromosome 1p34.1 and a member of peroxiredoxin family that contains a consensus site (Thr(90)-Pro-Lys-Lys) for phosphorylation by cyclin dependentkinases. This protein reduces the peroxidase activity by 80% through the thioredoxin system. Its phosphorylation is marked during mitosis yet undetectable at interphase, thus prevents the interaction of CDKs until breakdown of nuclear envelope during mitosis.

Peroxiredoxin 1 is implicated in redox regulation of the cell and plays an important role in eliminating peroxides produced during metabolism that participates in signaling of growth factors and tumornecrosis factor-alpha through regulating the intracellular concentrations of H2O2. It also stimulates TLR4 dependent cytokine secretion from macrophages and dendritic cells.

Peroxiredoxin 1 is overexpressed in several cancer cells including esophageal, pancreatic, lung,thyroid and oral cancer. Its concentration can be secreted by non-small cell lung cancer cells via unusual pathway. It is needed to activate Gde2 by reducing an intramolecular cysteine connection between N and C terminal domains for the induction of motor neuron differentiation.

Gene name: PRDX1

Protein name: Peroxiredoxin-1


Natural killer cell-enhancing factor A (NKEF-A)

Proliferation-associated gene protein (PAG)

Thioredoxin peroxidase 2

Thioredoxin-dependent peroxide reductase 2

See also:


Natural killer cell