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Pemphigus vulgaris

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pemphigus vulgaris

A serious form of pemphigus, occurring in middle age, in which cutaneous flaccid acantholytic suprabasal bullae and oral mucosal erosions may be localised a few months before becoming generalised; blisters break easily and are slow to heal; results from the action of autoimmune antibodies that localise to intercellular sites of stratified squamous epithelium.