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From Biology-Online Dictionary | Biology-Online Dictionary
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1. Full of pain; causing uneasiness or distress, either physical or mental; afflictive; disquieting; distressing

2. Requiring labour or toil; difficult; executed with laborious effort; as a painful service; a painful march.

3. Painstaking; careful; industrious. A very painful person, and a great clerk. (Jer. Taylor) Nor must the painful husbandman be tired. (Dryden)

Synonym: Disquieting, troublesome, afflictive, distressing, grievous, laborious, toilsome, difficult, arduous. Painfully, Painfulness.