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Ordered mechanism

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ordered mechanism

A scheme for substrate binding and product release for multisubstrate enzymes; for a two-substrate two-product enzyme with an ordered mechanism, one particular substrate has to bind to the enzyme first followed by the other substrate; chemistry then occurs, products are formed and are released from the enzyme in a distinct order. More complex ordered schemes exist for enzymes having more than two substrates. Some of the dehydrogenases have such a mechanism.

Synonym: ordered.