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Oncostatin M

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A member of cytokine family that has an inhibitory factor to severaltumor cell lines mediated through type II receptor protein.


Oncostatin M is a glycoprotein with a length of 196 amino acids that is mapped on chromosome 22q12-q12.2 at a distance of 16kb which synthesized as a forerunner of 252 amino acids by cleavage of secretory signal sequence of 25 amino acids from N-terminal end and 31 amino acids from C-terminal end that contains 5 cysteine residues which form disulfide bonds, thus essentials for the biological activity.

Oncostatin M manipulates the growth of endothelial cells and controls the production of plasminogen activator. It also plays a significant role in the regulation of myelopoiesis as such in hepatocytes it induces the synthesis of acute phase proteins. It has the capacity to inhibit the growth of human A357 melanoma cell but not in normal fibroblasts and the ability to inhibit the proliferation of leukemic cells thereby induce differentiation into macrophage-like cell. It also induces the synthesis of increased amounts of IL6 in Kaposi sarcoma cells.

Oncostatin M gene encodes growth regulator that inhibits the proliferation of tumor cell lines as well as in the cytokine production including IL-6, G-CSF and GM-CSF from endothelial cells. It supports the development of human fibroblasts, normal cell lines and vascular smooth muscle.

Gene name: OSM

Protein name: Oncostatin-M

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