Nuclear Respiratory Factor 1
A protein involved in thetranscriptional modulation of metabolic genes to cellular growth and development necessary for respiration, heme biosynthesis, mitochondrial DNA transcription and replication.
Nuclear Respiratory Factor 1 gene is mapped on chromosome 7q31 containing 503 amino acids span at about 53.5 kDa that has a binding elements present in gene involved in DNA replication, cytokinesis and mitosis. It is localizes in nucleus with two identified isoforms.
Nuclear Respiratory Factor 1 is abundantly expressed in skeletal muscle and has been first discovered as an activator of the cytochrome C gene. It also control cell adhesion, migration, proliferation, cell spreading, apoptosis and tumor invasion as well as redox signaling pathways via post-translational modifications and specific interaction with transcriptional co-activators.
Nuclear Respiratory Factor 1 implicated in type 2 diabetes and estrogen-dependent breast cancer in which binding signature is significantly enriched in the promoters of genes induced by estrogen wherein mitochondrial oxidant production prevent E2 induced expression of cell cycle genes containing NRF1 binding sites, thereby decrease E2 induced NRF1 expression resulted in the delay of growth thus, E2 stimulates NRF1 expression and cell progression of breast cancer cells via ROS by altering NRF1 activity.
Gene name: NRF1
Protein name: Nuclear respiratory factor 1