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Nomifensine

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nomifensine

(Science: chemical) 8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline. An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute haemolytic anaemia with intravascular haemolysis resulting from its use. In some cases, renal failure also developed.

Pharmacological action: dopamine uptake inhibitors.

Chemical name: 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-