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Nnrti

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NNRTI

A member of a class of compounds, including delavirdine, loviride and nevirapine, that acts to directly combine with and block the action of HIV's reverse transcriptase (see). In contrast, nucleoside analogs block reverse transcriptase by capping the unfinished dNA chain that the enzyme is constructing. NNRTIs have suffered from HIV's ability to rapidly mutate and become resistant to their effects.