Neuropilin 1 gene is mapped on chromosome 10 that encodes two neuropilins containing specific protein domains to participate in various signaling pathways that control cell migration. It has an N-terminal extracellular domain finished from complement-binding coagulation factor V and meprins which is also contain small spanning and small cytoplasmic domain.
Neuropilin 1 is a receptor involved in axon guidance expressed in dendritic cell and resting T cells, thus it mediates the interactions of dendritic cells and T cells which both significant for initiation of the primary immune responses. It also plays versatile role in angiogenesis, cell survival, axon guidance, invasion and migration. Soluble neuropilin 1 interacts in hemophilic manner on both dendritic and T cells.
Neuropilin 1 mediates an interaction to the essential element in the initiation of the primary immune response like agrin molecule necessary for neurologic and immunologic synapses. It is also involved in the development of cardiovascular system, formation of the neuronal circuits and organogenesis outside the nervous system.
Gene name: NRP1
Protein name: Neuropilin-1